Sequential and structural analysis of avian influenza A virus genome

Term: 2006 - 2009

Coiled coil proteins can perform a variety of important biological functions like regulating gene expression and maintaining the structural identity of the cell. They also play an integral role in the infectious mechanism of pathogens like Avian Influenza (bird flu) or HIV. Enveloped viruses enter cells by membrane fusion using specialized envelope glycoproteins, i.e. coiled coil fusion proteins, that form a sophisticated molecular machine to merge viral and cellular target membranes.

In order to design new drugs that inhibit the mechanism of virus-cell membrane fusion we aim to achieve a deeper understanding of the properties that inflluence stoichiometry and affinity of coiled coil proteins by applying machine learning methods.