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Correction of the Length-Year Relation For Archaic Genomes

The genomes of the Neandertals and the Denisovans are older than present human genomes, therefore the assumptions that $ g$ generations separate the first haplotype and $ g$ the second haplotype from a common ancestor are wrong.

The Neandertal bones from which the DNA was extracted were dated to 38,310 and 44,450 years before present day by carbon-14 accelerator mass spectrometry (28). This gives an average of 40 kya, which corresponds to 2,000 generations. The corrected formula for the average IBD segment length would be $ 100/(2g-2000)$ cM. The Denisovan finger bone from which the Denisovan DNA was sequenced is also dated back about 40 kya. Thus, 10 kbp correspond to 6,000 generations or to 120 kya and 20 kbp to 3,500 generations or 70 kya. The correction described above adds 1,000 generations or 20 kya as compared to the number if two present day genomes would have been compared, that is, if human IBD would be considered.


next up previous contents
Next: Length Correction for IBD Up: Relating the IBD Length Previous: Correction for the Assumptions   Contents
Sepp Hochreiter 2013-11-13